Product Overview

Piperine is a pungent compound found in black pepper (Piper nigrum) known for its various health benefits. It has a long history of use in Ayurvedic medicine as a restorative tonic and for enhancing the bioavailability of other foods and herbs in traditional herbal formulas (Prasad et al., 2015). Research has shown that Piperine can increase the bioavailability of turmeric root by 20-fold (Shoba et al., 1998).

The use of piperine extract derived from black pepper fruit dates back to ancient times, with references found in Sanskrit literature from as early as 100 BC. Black pepper was widely used in the Middle Ages to mask the taste of salt-cured meats and was highly valued, even serving as a form of currency. Its importance is evident in historical events, such as when 3000 pounds of black pepper were demanded alongside gold, silver, and silk as ransom to free Rome from the Huns (Prasad et al., 2015).

Piperine has been found to enhance the absorption of nutrients that are typically difficult for the body to metabolize. It may inhibit certain enzymes responsible for the nutrient breakdown and stimulate amino acid transporters in the intestinal lining, allowing for increased nutrient availability over an extended period (Atal et al., 1985; Bhardwaj et al., 2002). Additionally, Piperine may reduce intestinal activity, enabling more active components to enter the bloodstream in higher quantities. Its stimulating effect has been shown to support the release of digestive enzymes by the pancreas, leading to the reduced transit time of food in the gut. These effects contribute to the improved utilization of substances in the body, making black pepper or cayenne a common ingredient in traditional herbal formulas (Prasad et al., 2015).

Piperine has also demonstrated potential benefits for brain health due to its ability to cross the blood-brain barrier and facilitate the transport of other nutrients. It may support healthy levels of beta-endorphins and serotonin, positively influencing mood. Piperine is often regarded as a nourishing brain tonic and has directly affected various nutrients, including CoQ10, vitamin B6, curcumin, amino acids, selenium, and glucose. It can also affect the metabolism of certain enzymes, such as CYPLa1, CYP1b1, CYP1b2, CYP2e1, and CYP34a, as well as several over-the-counter and prescription drugs. It is important to be cautious of Piperine's ability to increase the bioavailability and potentially enhance the action of these medications (Atal et al., 1985; Bhardwaj et al., 2002; Prasad et al., 2015).

Scientific studies have provided further evidence of Piperine's benefits. A study published in the Journal of Food and Chemical Toxicology demonstrated that Piperine positively affected mood and cognitive performance at various doses, highlighting its potential as a powerful functional food for the brain (Mittal et al., 2012). Another study published in Planta Medica investigated the combination of Piperine with curcumin to evaluate curcumin's bioavailability in rats and healthy humans. The results showed that Piperine significantly increased the blood concentration of curcumin and enhanced its bioavailability by 2000% (Shoba et al., 1998).

Incorporating Piperine into your diet, whether as a supplement or through daily food intake, is a great way to add flavor to your meals while maximizing their nutritional benefits. Including spices in your daily routine can provide a powerful boost of nourishment (Prasad et al., 2015).

Some possible traditional uses of Piperine Extract Powder may include:

May support a healthy pain response
May support healthy levels of beta-endorphins
May support healthy serotonin & dopamine levels
May support healthy adrenals
May support a healthy gut
Bio enhancement
May support the production of pancreatic enzymes
May support a healthy inflammation response
Combating the formation of new fat cells
Combating malabsorption and malnutrition
May support a healthy histamine response
May support brain health
May support the transporting of other nutrients and herbs

This product is 100% natural and minimally processed. Taste, smell, texture, and color may vary from batch to batch.

CAUTION: Do not take it with medication.

Suggested Use: Take 10mg with any herb, nutrient, or spice mix to support better nonavailability.

Mixing Suggestions: To increase flavor and nutritional profile, combined with our organic turmeric, ginger, and cinnamon powders.

Botanical Name: Piper Nigrum L Seed.

Other Names: Pepper Extract.

Parts Used: Black Pepper.

Ingredients: Black Pepper Fruit Extract 40:1 (Yielding 95% Piperine).

Origin: Grown and extracted in China and packaged with care in Florida, USA.

Lean Factor strives to offer the highest quality organically grown, raw, vegan, gluten-free, non-GMO products available and exclusively uses low-temperature drying techniques to preserve all the vital enzymes and nutrients. Our 95% Piperine Extract Powder passes our strict quality assurance, which typically includes testing for botanical identity, heavy metals, chemicals, and microbiological contaminants. LeanFactor.com offers 95% Piperine Extract Powder packaged in airtight stand-up, resealable foil pouches for optimum freshness. Once opened, push the air out of the pouch before resealing it to preserve maximum potency. Keep your 95% Piperine Extract Powder in a cool, dark, dry place.

Sources & References

1. Atal, C. K., Dubey, R. K., & Singh, J. (1985). Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. Journal of Pharmacology and Experimental Therapeutics, 232(1), 258-262.

2. Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F. (2002). Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. Journal of Pharmacology and Experimental Therapeutics, 302(2), 645-650.

3. Mittal, R., Gupta, R. L., & Kumar, V. (2012). Piperine-mediated drug interactions and formulation strategy for piperine: recent advances and future perspectives. Journal of Food and Chemical Toxicology, 50(8), 647-655.

4. Prasad, S., Tyagi, A. K., & Aggarwal, B. B. (2015). Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Research and Treatment, 46(1), 2-18.

5. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. S. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353-356.

6. http://www.ncbi.nlm.nih.gov/pubmed/25479727

7. Murray, MT. The Healing Power of Foods. Prima Publishing, Rocklin, CA, 1993, pp. 211-212. 1993.

8. http://www.ncbi.nlm.nih.gov/pubmed/25446579

9. Mujumdar AM, Dhuley JN, Deshmukh VK, et al. Anti-inflammatory activity of Piperine. Jpn J Med Sci Biol 1990 Jun;43(3):95-100. 1990. PMID:16380.

10. http://www.ncbi.nlm.nih.gov/pubmed/25444919

11. Fortin, Francois, Editorial Director. The Visual Foods Encyclopedia. Macmillan, New York. 1996.

12. http://www.ncbi.nlm.nih.gov/pubmed/25438036

13. Grieve M. A Modern Herbal. Dover Publications, New York. 1971.

14. http://www.ncbi.nlm.nih.gov/pubmed/25384161

15. Grieve M. A Modern Herbal. Dover Publications, New York. 1971.

16. http://www.ncbi.nlm.nih.gov/pubmed/25375334

17. Ensminger AH, Ensminger M. K. J. e. al. Food for Health: A Nutrition Encyclopedia. Clovis, California: Pegus Press; 1986. 1986. PMID:15210.

18. http://www.ncbi.nlm.nih.gov/pubmed/25331343

19. Ensminger AH, Ensminger, ME, Kendale JE, Robson JRK. Foods & Nutrition Encyclopedia. Pegus Press, Clovis, California. 1983.

20. http://www.ncbi.nlm.nih.gov/pubmed/25327968

21. Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000 Feb;88(2):308-16. 2000. PMID:16390.

22. http://www.ncbi.nlm.nih.gov/pubmed/25173461

23. Calucci L, Pinzino C, Zandomeneghi M et al. Effects of gamma-irradiation on the free radical and antioxidant contents in nine aromatic herbs spices. J Agric Food Chem 2003 Feb 12; 51(4):927-34. 2003.

24. http://www.ncbi.nlm.nih.gov/pubmed/25166889

25. Ao P, Hu S, Zhao A. [Essential oil analysis and trace element study of the roots of Piper nigrum L.]. Zhongguo Zhong Yao Za Zhi 1998 Jan;23(1):42-3, 63. 1998. PMID:16370.

26. http://www.ncbi.nlm.nih.gov/pubmed/25153972

27. Merck Index, 11th Edition, 7442

28. http://www.ncbi.nlm.nih.gov/pubmed/25141367

29. Epstein, William W.; Netz, David F.; Seidel, Jimmy L. (1993). "Isolation of piperine from black pepper." J. Chem. Ed. 70 (7): 598. doi:10.1021/ed070p598.

30. http://www.ncbi.nlm.nih.gov/pubmed/25119528

31. Oersted, "Über das Piperin, ein neues Pflanzenalkaloid" [On piperine, a new plant alkaloid], (Schweigger's) Journal für Chemie und Physik, vol. 29, no. 1, pages 80-82 (1820).

32. http://www.ncbi.nlm.nih.gov/pubmed/25050023

33. McNamara FN, Randall A, Gunthorpe MJ (March 2005). "Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)". Br. J. Pharmacol. 144 (6): 781–90. doi:10.1038/SJ.bjp.0706040. PMC 1576058. PMID 15685214.

34. http://www.ncbi.nlm.nih.gov/pubmed/25027570

35. Atal CK, Dubey RK, Singh J (January 1985). "Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism." J. Pharmacol. Exp. Ther. 232 (1): 258–62. PMID 3917507.

36. http://www.ncbi.nlm.nih.gov/pubmed/24835937

37. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF (August 2002). "Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4". J. Pharmacol. Exp. Ther. 302 (2): 645–50. doi:10.1124/jpet.102.034728. PMID 12130727.

38. http://www.ncbi.nlm.nih.gov/pubmed/24819444

39. Srinivasan, K (2007). "Black pepper and its pungent principle-piperine: A review of diverse physiological effects." Critical Reviews in Food Science and Nutrition 47 (8): 735–48. doi:10.1080/10408390601062054. PMID 17987447.

40. http://www.ncbi.nlm.nih.gov/pubmed/24816193

41. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS (May 1998). "Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers." Planta Med. 64 (4): 353–6. doi:10.1055/s-2006-957450. PMID 9619120.

42. http://www.ncbi.nlm.nih.gov/pubmed/24525095

43. Wattanathorna, Jintanaporn; Pennapa Chonpathompikunlertb; Supaporn Muchimapuraa; Aroonsri Pripremc; Orathai Tankamnerdthai (September 2008). "Piperine, the potential functional food for mood and cognitive disorders." Food and Chemical Toxicology 46 (9): 3106–3110. doi:10.1016/j.fct.2008.06.014. PMID 18639606.

44. http://www.ncbi.nlm.nih.gov/pubmed/24418140

45. Singh J, Dubey RK, Ata CK l (1986). "Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content." Pharmacol. Exp. Ther. 236: 488–493.

46. http://www.ncbi.nlm.nih.gov/pubmed/24388894

47. Reen RK, Jamwal DS, Taneja SC, et al. (July 1993). "Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine." Biochem. Pharmacol. 46 (2): 229–38. doi:10.1016/0006-2952(93)90408-O. PMID 8347144.

48. http://www.ncbi.nlm.nih.gov/pubmed/24387754

49. Johnson, J. J.; Nihal, M; Siddiqui, I. A.; Scarlett, C. O.; Bailey, H. H.; Mukhtar, H; Ahmad, N (2011). "Enhancing the bioavailability of resveratrol by combining it with piperine." Molecular Nutrition & Food Research 55 (8): 1169–76. doi:10.1002/mnfr.201100117. PMC 3295233. PMID 21714124.

50. http://www.ncbi.nlm.nih.gov/pubmed/24370971

51. Faas, L.; Venkatasamy, R.; Hider, R. C.; Young, A. R.; Soumyanath, A. (2008). "In vivo evaluation of piperine and synthetic analogs as potential treatments for vitiligo using a sparsely pigmented mouse model." British Journal of Dermatology 158 (5): 941–50. doi:10.1111/j.1365-2133.2008.08464.x. PMID 18284389.

52. http://www.ncbi.nlm.nih.gov/pubmed/24348547

53. Ikan, Raphael (1991). Natural Products: A Laboratory Guide 2nd Ed. San Diego: Academic Press, Inc. pp. 223–224. ISBN 0123705517.

54. http://www.ncbi.nlm.nih.gov/pubmed/24329956

55. Gaikar. Process for extraction of piperine from piper species. US 6365601, April 2, 2002.

56. http://www.ncbi.nlm.nih.gov/pubmed/24260564

57. http://www.tis-gdv.de/tis_e/ware/gewuerze/pfeffer/pfeffer.htm#selbsterhitzung

58. http://www.ncbi.nlm.nih.gov/pubmed/24250643

59. Pharmacographia (London: Macmillan & Co., 1879), p. 584.

60. http://www.ncbi.nlm.nih.gov/pubmed/24193053

61. Annalen, 1850, 75, 82; 84, 345, cf. Wertheim and Rochleder, ibid., 1845, 54, 255.

62. http://www.ncbi.nlm.nih.gov/pubmed/24188307

63. Stenhouse in Pharm. J., 1855, 14, 363.

64. http://www.ncbi.nlm.nih.gov/pubmed/24050594

65. http://www.webmd.com/vitamins-supplements/ingredientmono-800-black%20pepper%20and%20white%20pepper.aspx?activeingredientid=800&activeingredientname=black%20pepper%20and%20white%20pepper

66. http://www.ncbi.nlm.nih.gov/pubmed/24005374

67. Majeed, M. Use of Piperine as a bioavailability enhancer. US Patent 5744161, October 26, 1999.

68. http://www.ncbi.nlm.nih.gov/pubmed/23993499

69. Babo & Keller, Journ. Pr. Chem., 1857, 72, 53.

70. http://www.ncbi.nlm.nih.gov/pubmed/23905652

71. Rugheimer, Ber., 1882, 15, 1390.

72. http://www.ncbi.nlm.nih.gov/pubmed/23895150

73. Manoharan S, Balakrishnan S, Menon V, et al. Singapore Med J. 2009 Feb;50(2):139-46.

74. http://www.ncbi.nlm.nih.gov/pubmed/23886380

75. "Pepper 'to treat pigment disease.'" BBC News. 2008-02-14.

76. http://www.ncbi.nlm.nih.gov/pubmed/23870999

77. Bang JS, Oh DH, Choi HM, et al. Arthritis Res Ther. 2009 Mar 30;11(2): R49.

78. http://www.ncbi.nlm.nih.gov/pubmed/23868040

79. Doucette CD, Hilchie AL, Liwski R, Hoskin DW. J Nutr Biochem 2013;24:231-239.

80. http://www.ncbi.nlm.nih.gov/pubmed/23838114

81. http://www.ncbi.nlm.nih.gov/pubmed/23824300

82. http://www.ncbi.nlm.nih.gov/pubmed/23791964

83. http://www.ncbi.nlm.nih.gov/pubmed/23768180

84. http://www.ncbi.nlm.nih.gov/pubmed/23750076

85. http://www.ncbi.nlm.nih.gov/pubmed/23625885

86. http://www.ncbi.nlm.nih.gov/pubmed/23153036

87. http://nutritionfacts.org/2015/02/05/why-pepper-boosts-turmeric-blood-levels/

88. http://ndb.nal.usda.gov/ndb/foods/show/261?fg=&man=&lfacet=&count=&max=35&sort=&qlookup=black+pepper&offset=&format=Full&new=&measureby=

89. http://www.ars-grin.gov/duke/

90. https://en.wikipedia.org/wiki/Piperonal

91. https://en.wikipedia.org/wiki/Piperine

92. https://www.naturalnews.com/2018-01-14-black-pepper-could-help-fight-obesity-research-shows-it-lower-body-fat-and-blood-sugar.html

93. https://www.ncbi.nlm.nih.gov/pubmed/28117414

94. https://www.ncbi.nlm.nih.gov/pubmed/28117414

95. https://www.ncbi.nlm.nih.gov/pubmed/28117414

96. https://www.ncbi.nlm.nih.gov/pubmed/28160856

97. https://www.ncbi.nlm.nih.gov/pubmed/28161984

98. https://www.ncbi.nlm.nih.gov/pubmed/28165813

99. https://www.ncbi.nlm.nih.gov/pubmed/28426244

100. https://www.ncbi.nlm.nih.gov/pubmed/28458425

101. https://www.ncbi.nlm.nih.gov/pubmed/28545378

102. https://www.ncbi.nlm.nih.gov/pubmed/28641526

103. https://www.ncbi.nlm.nih.gov/pubmed/28669317

104. https://www.ncbi.nlm.nih.gov/pubmed/28671634

105. https://www.ncbi.nlm.nih.gov/pubmed/28680454

106. https://www.ncbi.nlm.nih.gov/pubmed/28801675

107. https://www.ncbi.nlm.nih.gov/pubmed/28939403

108. https://www.ncbi.nlm.nih.gov/pubmed/28939512

109. https://www.ncbi.nlm.nih.gov/pubmed/28948673

110. https://www.ncbi.nlm.nih.gov/pubmed/28952262

111. https://www.ncbi.nlm.nih.gov/pubmed/29063362

112. https://www.ncbi.nlm.nih.gov/pubmed/29056550

113. https://www.ncbi.nlm.nih.gov/pubmed/29065496

114. https://www.ncbi.nlm.nih.gov/pubmed/29142409

115. https://www.ncbi.nlm.nih.gov/pubmed/29160763

116. https://www.ncbi.nlm.nih.gov/pubmed/29169726

117. https://www.ncbi.nlm.nih.gov/pubmed/29203239

118. https://www.ncbi.nlm.nih.gov/pubmed/29250980

119. https://www.ncbi.nlm.nih.gov/pubmed/29299200

120. https://www.ncbi.nlm.nih.gov/pubmed/29299989

121. https://www.ncbi.nlm.nih.gov/pubmed/25588261

122. https://www.ncbi.nlm.nih.gov/pubmed/3564049

123. https://www.ncbi.nlm.nih.gov/pubmed/8308845

124. https://www.ncbi.nlm.nih.gov/pubmed/23440300

125. https://www.ncbi.nlm.nih.gov/pubmed/23711775

126. https://www.ncbi.nlm.nih.gov/pubmed/24765585

127. https://www.ncbi.nlm.nih.gov/pubmed/26273991

128. https://www.ncbi.nlm.nih.gov/pubmed/27905507

129. https://www.ncbi.nlm.nih.gov/pubmed/28699236

130. https://www.ncbi.nlm.nih.gov/pubmed/29176994

131. https://www.ncbi.nlm.nih.gov/pubmed/29226913

132. Abila B, Richens A, Davies JA. Anticonvulsant effects of extracts of the West African black pepper, Piper guineense. J Ethnopharmacol 1993 Jun;39(2):113-7. 1993. PMID:16400.

133. http://www.ncbi.nlm.nih.gov/pubmed/25554982

134. http://www.whfoods.com/genpage.php?tname=foodspice&dbid=74#nutritionalprofile

135. http://www.ncbi.nlm.nih.gov/pubmed/25541091

136. Wood, Rebecca. The Whole Foods Encyclopedia. New York, NY: Prentice-Hall Press; 1988. 1988. PMID:15220.

Thermogenic

Feel Better. Look Better. Be Better.

Create Account

Welcome back

Forgot password

Activate your account

FIRST TIME ON OUR NEW SITE?